GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1552244 | 1 | rs66797209 | chr3:10078526 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.3 | 2.08E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs66797209 | chr3:10078526 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.42 | 1.24E-5 | Alzheimer's disease |
| THCA | cis | rs12762955 | 1 | rs66797613 | chr10:1090469 | IDI2 | chr10:1064847-1071799:- | -0.24 | -3.46 | 0.000597 | Response to angiotensin II receptor blocker therapy |
| THCA | cis | rs59374417 | 1 | rs66797637 | chr3:119279658 | ADPRH | chr3:119298523-119308791:+ | -0.22 | -3.51 | 0.000482 | Vitiligo |
| THCA | cis | rs1449984 | 1 | rs66798645 | chr2:23416836 | FKBP1B | chr2:24272584-24286548:+ | 0.18 | 3.5 | 0.000507 | Depression (quantitative trait) |
| THCA | cis | rs67335251 | 1 | rs66801518 | chr16:4073188 | NAT15 | chr16:3493668-3536962:+ | -0.29 | -3.56 | 0.000406 | Diisocyanate-induced asthma |
| THCA | cis | rs2275426 | 1 | rs6680380 | chr1:46300189 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -10.03 | 1.26E-21 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6680380 | chr1:46300189 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.07 | 5.44E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6680380 | chr1:46300189 | MMACHC | chr1:45965856-45976737:+ | -0.19 | -4.28 | 2.24E-5 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6680380 | chr1:46300189 | MUTYH | chr1:45794915-45806142:- | 0.31 | 8.34 | 7.9E-16 | Body mass index |
| THCA | cis | rs673604 | 1 | rs668092 | chr1:35687203 | ZMYM4 | chr1:35734568-35887544:+ | -0.13 | -3.46 | 0.000583 | Endometrial cancer |
| THCA | cis | rs1552244 | 1 | rs66838678 | chr3:10150350 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.51 | 8.24E-6 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs66838678 | chr3:10150350 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.44 | 1.13E-5 | Alzheimer's disease |
| THCA | cis | rs6684514 | 1 | rs6684514 | chr1:156255456 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 5.47 | 7.46E-8 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs6684514 | chr1:156255456 | C1orf85 | chr1:156259882-156265449:- | -0.17 | -4.03 | 6.45E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |